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KMID : 0861020030180040289
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Korea Journal of Herbology
2003 Volume.18 No. 4 p.289 ~ p.299
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Studies on the Acetylcholinesterase inhibitors Effects of Cuscutae Semen
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Abstract
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Objectives : In the course of searching for acetylcholinesterase(AChE) inhibitors from Semen of Cuscuta Australis R. BR in Korea and Cuscuta Austmlis R. BR in ChiM
This study was carried out to investigate the effects protecting or improving Alzheimer´s disease of the acetylcholimsterase(AChE) inhibitors.
Methods : This oriental drugs was extracted with 8oo/o methanol in room temperature and the extract was fives fractionation by hexane, chlorofm, ethylacetate, butanol and water.
A mouse model of passive avoidance was used for recovery effect of Cuscutu Austmlis R. BR in Korea and Cuscuta Austmlis R. BR in China. on learning and memory deficits induced by scopolamine..
Results :
1. Acetylcholinesterase(AChE) inhibitors of Cuscuta Austmlis R. BR in Korea and Cuscutu Austmlis R. BR in China were investigated. It was found that Cuscuta Austmlis R. BR in Korea(64%) showed significantly inhibitory effect on AChE than in the Cuscuta Austmlis R. BR in China (29%).
2. Recovery effect on scopolamine-induced memory impairment in a mouse model of passive avoidance of Cuscuta Austmlis R. BR in Korea and Cuscuta Australis R. BR in China were investigated. Cuscuta Austmlis R. BR in Korea showed significant recovery effect on than Cuscuta Australis R. BR in China.
3. Acetylcholinesterase(AChE) inhibitors for recovery effect on scopolamine - induced memory impairment in a mouse model of passive avoidance of Cuscuta Australis R. BR in Korea and Cuscuta Australis R. BR in China were investigated. Cuscuta Australis R. BR in Korea increased acetylcholinesterase (AChE) inhibitors than Cuscuta Austmlis R. BR in China
4. The activity of DPPH and SOD of Cuscuta Austmlis R. BR in Korea were increase than Cuscuta Australis R. BR in China, but catalase were decrease than Cuscuta Austmlis R. BR in China.
Conclusion : According to the above results, we found that ethylacetate extract of Semen of Cuscuta Austmlis R. BR in Korea showed significant inhibitory effect on AChE.
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